Meta-analyses suggest berberine can lower fasting glucose and HbA1c in type 2 diabetes and improve lipid fractions, especially as an adjunct to lifestyle or medication. Safety signals in trials are generally tolerable, with gastrointestinal effects most common.
For the gut, zinc-carnosine combinations have been studied as adjuncts in H. pylori eradication and mucosal support, though these belong in a targeted protocol after proper diagnosis.
Use case, dose, and interactions matter. Treat berberine as a tool inside a wider plan… check medications for interactions, cycle intelligently, and let lab data, not headlines, decide whether it is earning its keep.